Search Results - rosalie+dohmen

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Protein engineering and protein optimization based on ancestral sequence reconstruction using evolutionary molecular meandering and fitness well dragging

BACKGROUND An Ancestral Sequence Reconstruction (ASR) highlights the evolutionary pathway of proteins and how some protein homologs have differed in both structural and functional composition throughout evolution. These differing compositions have resulted in proteins with variable abilities, which may have previously been overlooked due to the lack...

Published: 6/27/2025 | Inventor(s): Wouter Hoff, Rosalie Dohmen

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Category(s): Technology Classifications > Biotech & Pharmaceutical, Technology Classifications > Agriculture & Food Science

Homology-based derivation of structure-function rule for protein families

BACKGROUND A long-standing challenge within protein science and engineering is that different members of a protein family have functionally distinct properties. It is observable that two members of a protein family each have a property which is helpful for a specific application. For example, if one homolog can exhibit high thermal stability while...

Published: 8/7/2023 | Inventor(s): Wouter Hoff, Rosalie Dohmen

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Category(s): Technology Classifications > Biotech & Pharmaceutical