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Incorporation of the Horseradish Peroxidase Gene in a Viral Genome Provides a Rapid and Cost-effective in vitro Method to Determine the Antiviral Potential of Antibodies or Drugs

BACKGROUND In-vitro virus neutralization assays are an important step in determining potential in-vivo efficacy of vaccines or (synthetic) anti-viral antibodies. Most recent micro-neutralization assays are based on luciferase or fluorescence read-outs. Viruses of interest are modified by inserting genes encoding luciferase or fluorescent proteins....

Published: 5/31/2023 | Inventor(s): Pramila Lamichhane, Antonius (Tom) Oomens

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Category(s): Technology Classifications > Research Tools, Technology Classifications > Biotech & Pharmaceutical