BACKGROUND
Bleeding is responsible for 30–40% of deaths in the initial hours after injury. Hemostasis, or the formation of stable blood clots, after a severe injury is necessary to prevent major blood loss and death from hemorrhagic shock. Also, providing a closure that seals the wound completely accelerates the healing process. For these two aims, different methods and different types of healing systems have been introduced. One of the most innovative ways for healing of acute wounds is using bio-adhesives. Bio-adhesives are biocompatible, hemostatic materials that can help with blood clotting and wound healing. However, there are some problems with bio-adhesives: natural bio-adhesives have poor mechanical properties, and synthetic bio-adhesives exhibit poor biocompatibility. Thus, there is still an urgent need for adhesives for wound care.
SUMMARY OF TECHNOLOGY
Researchers at OSU have synthesized an injectable hemostatic bio-adhesive with controlled degradability, tissue-like elastomeric mechanical properties, and excellent cyto/tissue-compatibility. Such a bio-adhesive stops bleeding in a few seconds and, allows for suture-less wound closing. This is currently impossible using the existing standard, fibrin glue, due to its weak wet tissue adhesion strength. The new bio-adhesives facilitate wound healing and are wholly degraded and absorbed without eliciting a significant inflammatory response. Our results support that this technology is highly translational and could have a broad impact on surgeries where surgical tissue adhesives, sealants, and hemostatic agents are used.
POTENTIAL AREAS OF APPLICATION
MAIN ADVANTAGES
STAGE OF DEVELOPMENT
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