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Novel Method for Enhancing RSV Vaccine Efficacy/Safety by Combining Live-Attenuated Virus and VLPs

BACKGROUND Respiratory syncytial virus (RSV) is the single largest cause of viral pediatric bronchiolitis and pneumonia in the world; in 2015, 33.1 million RSV associated acute respiratory infections (ARI) in children resulted in 3.2 million hospitalizations and 59,600 deaths globally. Pursuit of a vaccine for this disease has been ongoing since...

Published: 5/31/2023 | Inventor(s): Antonius (Tom) Oomens

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Category(s): Technology Classifications > Biotech & Pharmaceutical

RSV-Based Virus-Like Particles as Vaccines

BACKGROUND Respiratory syncytial virus (RSV) is the single largest cause of viral pediatric bronchiolitis and pneumonia in the world; in 2015, 33.1 million RSV associated acute respiratory infections (ARI) in children resulted in 3.2 million hospitalizations and 59,600 deaths globally. This disease is also dangerous to people over 65 with 1.5...

Published: 5/31/2023 | Inventor(s): Antonius (Tom) Oomens

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Category(s): Technology Classifications > Biotech & Pharmaceutical

Incorporation of the Horseradish Peroxidase Gene in a Viral Genome Provides a Rapid and Cost-effective in vitro Method to Determine the Antiviral Potential of Antibodies or Drugs

BACKGROUND In-vitro virus neutralization assays are an important step in determining potential in-vivo efficacy of vaccines or (synthetic) anti-viral antibodies. Most recent micro-neutralization assays are based on luciferase or fluorescence read-outs. Viruses of interest are modified by inserting genes encoding luciferase or fluorescent proteins....

Published: 5/31/2023 | Inventor(s): Pramila Lamichhane, Antonius (Tom) Oomens

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Category(s): Technology Classifications > Research Tools, Technology Classifications > Biotech & Pharmaceutical

Engineered Respiratory Syncytial Viruses with Control of Cell-to-Cell Virus Transmission for Enhanced Safety of Live Virus Vaccines

BACKGROUND Respiratory Syncytial Virus (RSV) is the largest viral cause of pediatric bronchiolitis worldwide, a respiratory disease that results in over 100,000 deaths per year. RSV can also cause adult lung diseases such as pneumonia and poses a serious risk for the elderly and the immunocompromised. Unfortunately, a vaccine for RSV is not currently...

Published: 10/19/2022 | Inventor(s): Antonius (Tom) Oomens

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

A safe, self-limited, live RSV vaccine expressing pre-fusion conformation - stabilized fusion protein, and inducing both humoral and cellular anti-RSV immunity

BACKGROUND Respiratory Syncytial Virus (RSV) is the single largest viral cause of pediatric bronchiolitis and pneumonia, with a high worldwide mortality, and there is no safe and effective vaccine. Ever since the encounter with vaccine-enhanced disease (VED) during a formalin-inactivated RSV vaccination trial in the 1960s, it has been enormously...

Published: 5/31/2023 | Inventor(s): Antonius (Tom) Oomens

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical