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A Novel Treatment for Cystic Fibrosis Patients with Non-Tuberculous Mycobacterial Infection

BACKGROUND Non-tuberculous Mycobacteria (NTM) are a group of opportunistic bacterial pathogens, which can cause severe pulmonary infections in people with an immunocompromised condition, such as cystic fibrosis (CF). 2,990 people died primarily from NTM in the United States between 1999-2010; these data also show a significant increase in deaths across...

Published: 5/31/2023 | Inventor(s): Yong Cheng, Jeffrey Schorey, Xuejuan Tan

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Multiplex-Based Assay to Characterize ADAMTS13 Properties and Function

BACKGROUND The metalloprotease ADAMTS13 regulates the platelet adhesion by von Willebrand factor (VWF) by severing large, prothrombotic VWF-Platelet aggregates. Genetic or autoimmune deficiency of ADAMTS13 impairs this regulatory mechanism causing thrombotic thrombocytopenic purpura (TTP), a rare fatal blood clotting disorder characterized by microangiopathic...

Published: 5/17/2023 | Inventor(s): Joshua Muia, Frida Miranda

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Cellular Senescence as a Biomarker for Cystic Fibrosis Lung Disease

BACKGROUND Cystic fibrosis (CF) is a genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and affects ~30,000 people in the USA alone. Microbial lung infections are currently one of the main causes of mortality and morbidity in CF patients. 2,990 people died primarily from non-tuberculosis mycobacterial...

Published: 5/31/2023 | Inventor(s): Yong Cheng, Xuejuan Tan

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Artificial Intelligence Enabled Software for Mechanical Characterizations of Thin, Soft, Heterogeneous Bio-Tissues

BACKGROUND Heterogeneous membranes or films are thin and soft structures with spatial variations in material property and thickness. Important heterogeneous membranes include bio tissues such as heart valves, eardrum membranes, skin, as well as artificial synthesized bio-compatible tissues, non-woven materials. Mechanical behavior of heterogeneous...

Published: 8/18/2023 | Inventor(s): Lin Guo, Shuodao Wang, Yuan Zhang

Keywords(s): Biotech & Pharmaceutical, Medical Device & Diagnostic, Software: AI, Neural Network & Learning

Category(s): Technology Classifications > Software, Technology Classifications > Biotech & Pharmaceutical, Technology Classifications > Medical Device & Diagnostic

Software for Real-Time Monitoring and Fault Detection of Chemical Distillation Process

BACKGROUND In recent decades, the chemical, refining, petrochemical, pharmaceutical, and agrochemical process industries have actively adopted distributed control systems (DCSs) to digitally monitor and control their plant operations. These commercial DCSs can provide process monitoring, control, and limited alarm management capabilities. In particular,...

Published: 4/26/2023 | Inventor(s): Zheyu Jiang

Keywords(s): Biotech & Pharmaceutical, Chemistry, Engineering: Chemical, Petroleum, Engineering: Electrical & Computer, Sensors, Software

Category(s): Technology Classifications > Software, Technology Classifications > Engineering > Chemical Engr, Technology Classifications > Engineering

Digital Twin System for Human Pulmonary Healthcare

BACKGROUND Pulmonary diseases such as chronic obstructive pulmonary disease (COPD) was the third-leading cause of death globally in 2019. While there is no cure for COPD, treatments are available and are constantly being developed. Numerical modelling of pulmonary air-particle dynamics is a crucial tool for assessing drug distribution efficacy...

Published: 5/24/2023 | Inventor(s): Yu Feng, Jianan Zhao

Keywords(s): Biotech & Pharmaceutical, Engineering, Medical Device & Diagnostic, Software, Software: AI, Neural Network & Learning

Category(s): Technology Classifications > Medical Device & Diagnostic, Technology Classifications > Biotech & Pharmaceutical

Metabolites of SHetA2 as Anti-Cancer Agents

BACKGROUND SHetA2 has previously been identified by OSU researchers as a strong anti-cancer agent that induces apoptosis (cell death) in 8 different types of kidney cancer cells and is being developed for treatment of Polycystic Kidney Disease (PKD). SHetA2 is in the final stages of preclinical testing and since no toxicity to normal cells has been...

Published: 10/19/2022 | Inventor(s): Doris Benbrook, Richard Bunce, Kenneth Berlin

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Engineered Respiratory Syncytial Viruses with Control of Cell-to-Cell Virus Transmission for Enhanced Safety of Live Virus Vaccines

BACKGROUND Respiratory Syncytial Virus (RSV) is the largest viral cause of pediatric bronchiolitis worldwide, a respiratory disease that results in over 100,000 deaths per year. RSV can also cause adult lung diseases such as pneumonia and poses a serious risk for the elderly and the immunocompromised. Unfortunately, a vaccine for RSV is not currently...

Published: 10/19/2022 | Inventor(s): Antonius (Tom) Oomens

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Method and component of a novel antiviral targeting type 1 interferon response

BACKGROUND Influenza virus infection results in 200,000 hospitalizations, 36,000 deaths, and $87 billion in healthcare costs per year in the U.S. The current treatments, which consist of antiviral drugs that target viral proteins, only work if new strains of influenza virus do not emerge. However, influenza viral proteins readily mutate to create new,...

Published: 10/19/2022 | Inventor(s): Yujie Guo, Lin Liu

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Antimicrobial, thermally and visible light stable silver (I) cyanoximates that inhibit biofilm formation

BACKGROUND Hospital-acquired infections are becoming more prevalent worldwide. According to the CDC, 1.7 million patients in the US acquire infections during their hospital stay, which costs $6.7 billion dollars annually. Fifty-four percent of hospital-acquired infections occur at surgical sites or in urinary tracts, and are increasingly caused by...

Published: 10/19/2022 | Inventor(s): Nikolay Gerasimchuk, Marianna Patrauchan

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Medical Device & Diagnostic, Technology Classifications > Biotech & Pharmaceutical

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