Search Results - richard+bunce

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Inhibitors of Protein-Protein Interactions to Disrupt Bacterial Iron Homeostasis

BACKGROUND The emergence of antibiotic resistant bacteria, and a marked decrease in the development of new antibiotics threaten to severely undermine many of the advances in modern medicine. Most antibiotics target a limited number of crucial biological processes, including DNA replication, protein translation, and cell wall biosynthesis. Thus,...

Published: 5/31/2023 | Inventor(s): Mario Rivera, Huili Yao, Kate Eshelman, Achala Punchi Hewage, Scott Lovell, Baskar Nammalwar, Krishna Gnanasekaran, Richard Bunce

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Category(s): Technology Classifications > Biotech & Pharmaceutical

Metabolites of SHetA2 as Anti-Cancer Agents

BACKGROUND SHetA2 has previously been identified by OSU researchers as a strong anti-cancer agent that induces apoptosis (cell death) in 8 different types of kidney cancer cells and is being developed for treatment of Polycystic Kidney Disease (PKD). SHetA2 is in the final stages of preclinical testing and since no toxicity to normal cells has been...

Published: 10/19/2022 | Inventor(s): Doris Benbrook, Richard Bunce, Kenneth Berlin

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Chroman and Tetrahydroquinoline-Derived Heteroarotinoids as Agents to Treat Human Ovarian Cancer

BACKGROUND Advanced stage malignant ovarian cancer (MOC) is an incurable disease of women, resistant to chemotherapies with agents such as cisplatin, carboplatin and taxane. MOC chemotherapies also have limited tumor specificity and cause significant toxicity, resulting in modest efficacy and recurrence in greater than 70% of treated patients. Thus,...

Published: 5/31/2023 | Inventor(s): Richard Bunce, Krishna Gnanasekaran, Field Watts, Donghua Zhou, Doris Benbrook, Kenneth Berlin

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Category(s): Technology Classifications > Biotech & Pharmaceutical

Inhibitors of the BfrB-Bfd Complex for Killing Biofilm Bacteria

BACKGROUND Biofilms are communities of microbes adhering to a surface and often embedded in an extracellular matrix. As a result of this structure, biofilms exhibit resistance to both host immune responses and antibiotics. Approximately 80% of human bacterial infections involve biofilms; this can take the form of chronic wound infections, chronic...

Published: 5/31/2023 | Inventor(s): Huili Yao, Anabel Soldano, Scott Lovell, Richard Bunce, Mario Rivera

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Category(s): Technology Classifications > Biotech & Pharmaceutical