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Chroman and Tetrahydroquinoline-Derived Heteroarotinoids as Agents to Treat Human Ovarian Cancer

BACKGROUND Advanced stage malignant ovarian cancer (MOC) is an incurable disease of women, resistant to chemotherapies with agents such as cisplatin, carboplatin and taxane. MOC chemotherapies also have limited tumor specificity and cause significant toxicity, resulting in modest efficacy and recurrence in greater than 70% of treated patients. Thus,...

Published: 5/31/2023 | Inventor(s): Richard Bunce, Krishna Gnanasekaran, Field Watts, Donghua Zhou, Doris Benbrook, Kenneth Berlin

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Category(s): Technology Classifications > Biotech & Pharmaceutical