Search Results - krishna+gnanasekaran

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Inhibitors of Protein-Protein Interactions to Disrupt Bacterial Iron Homeostasis

BACKGROUND The emergence of antibiotic resistant bacteria, and a marked decrease in the development of new antibiotics threaten to severely undermine many of the advances in modern medicine. Most antibiotics target a limited number of crucial biological processes, including DNA replication, protein translation, and cell wall biosynthesis. Thus,...

Published: 5/31/2023 | Inventor(s): Mario Rivera, Huili Yao, Kate Eshelman, Achala Punchi Hewage, Scott Lovell, Baskar Nammalwar, Krishna Gnanasekaran, Richard Bunce

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Category(s): Technology Classifications > Biotech & Pharmaceutical

Chroman and Tetrahydroquinoline-Derived Heteroarotinoids as Agents to Treat Human Ovarian Cancer

BACKGROUND Advanced stage malignant ovarian cancer (MOC) is an incurable disease of women, resistant to chemotherapies with agents such as cisplatin, carboplatin and taxane. MOC chemotherapies also have limited tumor specificity and cause significant toxicity, resulting in modest efficacy and recurrence in greater than 70% of treated patients. Thus,...

Published: 5/31/2023 | Inventor(s): Richard Bunce, Krishna Gnanasekaran, Field Watts, Donghua Zhou, Doris Benbrook, Kenneth Berlin

Keywords(s):

Category(s): Technology Classifications > Biotech & Pharmaceutical