Search Results - huili+yao

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Inhibitors of Protein-Protein Interactions to Disrupt Bacterial Iron Homeostasis

BACKGROUND The emergence of antibiotic resistant bacteria, and a marked decrease in the development of new antibiotics threaten to severely undermine many of the advances in modern medicine. Most antibiotics target a limited number of crucial biological processes, including DNA replication, protein translation, and cell wall biosynthesis. Thus,...

Published: 5/31/2023 | Inventor(s): Mario Rivera, Huili Yao, Kate Eshelman, Achala Punchi Hewage, Scott Lovell, Baskar Nammalwar, Krishna Gnanasekaran, Richard Bunce

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Category(s): Technology Classifications > Biotech & Pharmaceutical

Inhibitors of the BfrB-Bfd Complex for Killing Biofilm Bacteria

BACKGROUND Biofilms are communities of microbes adhering to a surface and often embedded in an extracellular matrix. As a result of this structure, biofilms exhibit resistance to both host immune responses and antibiotics. Approximately 80% of human bacterial infections involve biofilms; this can take the form of chronic wound infections, chronic...

Published: 5/31/2023 | Inventor(s): Huili Yao, Anabel Soldano, Scott Lovell, Richard Bunce, Mario Rivera

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Category(s): Technology Classifications > Biotech & Pharmaceutical