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2023-0024 Tech Summary Application of Cellular Senescence Drugs in Cystic Fibrosis Patients with Lung Infections

BACKGROUND Cystic Fibrosis (CF) is a genetic disorder that affects approximately 100,000 individuals worldwide, causing severe health issues, particularly in the lungs. The condition is the result of mutations in the CFTR gene, which is responsible for producing a protein that regulates the movement of chloride and bicarbonate across cell membranes....

Published: 9/12/2024 | Inventor(s): Yong Cheng, Xuejuan Tan

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Category(s): Technology Classifications > Biotech & Pharmaceutical

A Novel Treatment for Cystic Fibrosis Patients with Non-Tuberculous Mycobacterial Infection

BACKGROUND Non-tuberculous Mycobacteria (NTM) are a group of opportunistic bacterial pathogens, which can cause severe pulmonary infections in people with an immunocompromised condition, such as cystic fibrosis (CF). 2,990 people died primarily from NTM in the United States between 1999-2010; these data also show a significant increase in deaths across...

Published: 5/31/2023 | Inventor(s): Yong Cheng, Jeffrey Schorey, Xuejuan Tan

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Cellular Senescence as a Biomarker for Cystic Fibrosis Lung Disease

BACKGROUND Cystic fibrosis (CF) is a genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and affects ~30,000 people in the USA alone. Microbial lung infections are currently one of the main causes of mortality and morbidity in CF patients. 2,990 people died primarily from non-tuberculosis mycobacterial...

Published: 5/31/2023 | Inventor(s): Yong Cheng, Xuejuan Tan

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical