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Multiplex-Based Assay to Characterize ADAMTS13 Properties and Function

BACKGROUND The metalloprotease ADAMTS13 regulates the platelet adhesion by von Willebrand factor (VWF) by severing large, prothrombotic VWF-Platelet aggregates. Genetic or autoimmune deficiency of ADAMTS13 impairs this regulatory mechanism causing thrombotic thrombocytopenic purpura (TTP), a rare fatal blood clotting disorder characterized by microangiopathic...

Published: 9/6/2024 | Inventor(s): Joshua Muia, Frida Miranda

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical