Search Results - wouter+hoff

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Homology-based derivation of structure-function rule for protein families

BACKGROUND A long-standing challenge within protein science and engineering is that different members of a protein family have functionally distinct properties. It is observable that two members of a protein family each have a property which is helpful for a specific application. For example, if one homolog can exhibit high thermal stability while...

Published: 8/7/2023 | Inventor(s): Wouter Hoff, Rosalie Dohmen

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Category(s): Technology Classifications > Biotech & Pharmaceutical

A Novel Class of Therapeutic Peptides

BACKGROUND Protein misfolding is thought to be the cause of many degenerative and neurodegenerative diseases such as Huntington’s disease, Parkinson’s, Alzheimer’s, and cystic fibrosis. Oftentimes the result of this misfolding is aggregations of misfolded proteins. There are some therapies to try and treat misfolded proteins...

Published: 5/24/2023 | Inventor(s): Wouter Hoff

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Category(s): Technology Classifications > Biotech & Pharmaceutical

Combining site-directed mutations and reconstitution with a locked chromophore analog converts photoactive yellow protein into a highly fluorescent protein tag

BACKGROUND Fluorescent protein tags, such as green fluorescent protein (GFP), exhibit fluorescence when viewed under ultraviolet light. Since these tags make it possible to 'see' metabolic interactions, attaching them to proteins, antibodies, and amino acids allows researchers to study interactions between biomolecules and thus improve our...

Published: 10/19/2022 | Inventor(s): Masato Kumauchi, Branden Carr, Wouter Hoff

Keywords(s): Research Tools & Methods

Category(s): Technology Classifications > Research Tools