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Point-of-Need Colorimetric Serum and Salivary Insulin Immunosensor

BACKGROUND Diabetes is a chronic disease characterized by impaired insulin production or action, resulting in poor regulation of glucose. While current continuous glucose monitoring (CGM) technologies are vital tools for diabetes management, they primarily measure glucose, which exists at high (millimolar) concentrations. However, insulin, the hormone...

Published: 8/14/2025 | Inventor(s): Sadagopan Krishnan

Keywords(s):

Category(s): Technology Classifications > Biotech & Pharmaceutical, Technology Classifications > Animal Health

Discovery of ammonium salts of alpha-fluoroarylated Meldrum's acid derivatives

BACKGROUND Meldrum’s acid is widely used as a building block in the synthesis of diverse organic compounds, including natural products and pharmaceuticals. Despite its broad utility, efficient and general methods for the direct mono-arylation of Meldrum’s acid remain limited. At the same time, there is a growing demand for partially fluorinated...

Published: 8/11/2025 | Inventor(s): Sameera Senaweera, Jimmie Weaver

Keywords(s): Research Tools & Methods

Category(s): Technology Classifications > Biotech & Pharmaceutical

Protein engineering and protein optimization based on ancestral sequence reconstruction using evolutionary molecular meandering and fitness well dragging

BACKGROUND An Ancestral Sequence Reconstruction (ASR) highlights the evolutionary pathway of proteins and how some protein homologs have differed in both structural and functional composition throughout evolution. These differing compositions have resulted in proteins with variable abilities, which may have previously been overlooked due to the lack...

Published: 6/27/2025 | Inventor(s): Wouter Hoff, Rosalie Dohmen

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Category(s): Technology Classifications > Biotech & Pharmaceutical, Technology Classifications > Agriculture & Food Science

PulmoPrecise: Artificial Intelligence (AI) Empowered User-Centered Smart Inhaler for Targeted Drug Delivery to Designated Lung Sites

Background Managing pulmonary diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis presents considerable challenges, particularly in achieving directed drug delivery to the lungs at the necessary doses. The primary approach for both long-term treatment and rescue drug delivery involves the use of inhaler devices, wherein...

Published: 3/26/2025 | Inventor(s): Yu Feng

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Category(s): Technology Classifications > Biotech & Pharmaceutical, Technology Classifications > Software

A novel class of antibiotics against non-tuberculous mycobacterial infection

BACKGROUND Nontuberculous mycobacteria (NTM) infections are becoming an increasing public health concern, particularly for individuals with chronic lung conditions, those who are immunosuppressed, or people exposed to contaminated water sources. Unlike tuberculosis, which is caused by Mycobacterium tuberculosis, NTM includes over 190 species, many...

Published: 2/7/2025 | Inventor(s): Yong Cheng, Xuejuan Tan, Audrey Dagnell

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Category(s): Technology Classifications > Animal Health, Technology Classifications > Biotech & Pharmaceutical

Lifespan Prolonging Probiotic

BACKGROUND Probiotics, which are live microorganisms known to promote gut health, have attracted significant attention for their ability to positively impact the gut microbiome. By improving digestion, nutrient absorption, and immune function, these beneficial bacteria contribute to overall health. Recent studies have also suggested that probiotics...

Published: 10/31/2024 | Inventor(s): Jacob Manjarrez, Ratnakar Deole

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Category(s): Technology Classifications > Biotech & Pharmaceutical

2023-0024 Tech Summary Application of Cellular Senescence Drugs in Cystic Fibrosis Patients with Lung Infections

BACKGROUND Cystic Fibrosis (CF) is a genetic disorder that affects approximately 100,000 individuals worldwide, causing severe health issues, particularly in the lungs. The condition is the result of mutations in the CFTR gene, which is responsible for producing a protein that regulates the movement of chloride and bicarbonate across cell membranes....

Published: 9/12/2024 | Inventor(s): Yong Cheng, Xuejuan Tan

Keywords(s):

Category(s): Technology Classifications > Biotech & Pharmaceutical

Homology-based derivation of structure-function rule for protein families

BACKGROUND A long-standing challenge within protein science and engineering is that different members of a protein family have functionally distinct properties. It is observable that two members of a protein family each have a property which is helpful for a specific application. For example, if one homolog can exhibit high thermal stability while...

Published: 8/7/2023 | Inventor(s): Wouter Hoff, Rosalie Dohmen

Keywords(s):

Category(s): Technology Classifications > Biotech & Pharmaceutical

A Novel Treatment for Cystic Fibrosis Patients with Non-Tuberculous Mycobacterial Infection

BACKGROUND Non-tuberculous Mycobacteria (NTM) are a group of opportunistic bacterial pathogens, which can cause severe pulmonary infections in people with an immunocompromised condition, such as cystic fibrosis (CF). 2,990 people died primarily from NTM in the United States between 1999-2010; these data also show a significant increase in deaths across...

Published: 5/7/2025 | Inventor(s): Yong Cheng, Jeffrey Schorey, Xuejuan Tan

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Multiplex-Based Assay to Characterize ADAMTS13 Properties and Function

BACKGROUND The metalloprotease ADAMTS13 regulates the platelet adhesion by von Willebrand factor (VWF) by severing large, prothrombotic VWF-Platelet aggregates. Genetic or autoimmune deficiency of ADAMTS13 impairs this regulatory mechanism causing thrombotic thrombocytopenic purpura (TTP), a rare fatal blood clotting disorder characterized by microangiopathic...

Published: 9/6/2024 | Inventor(s): Joshua Muia, Frida Miranda

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

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