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Tech Summary 2024-038 Lifespan Prolonging Probiotic

BACKGROUND Probiotics, which are live microorganisms known to promote gut health, have attracted significant attention for their ability to positively impact the gut microbiome. By improving digestion, nutrient absorption, and immune function, these beneficial bacteria contribute to overall health. Recent studies have also suggested that probiotics...

Published: 9/12/2024 | Inventor(s): Jacob Manjarrez, Ratnakar Deole

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Category(s): Technology Classifications > Biotech & Pharmaceutical

2023-0024 Tech Summary Application of Cellular Senescence Drugs in Cystic Fibrosis Patients with Lung Infections

BACKGROUND Cystic Fibrosis (CF) is a genetic disorder that affects approximately 100,000 individuals worldwide, causing severe health issues, particularly in the lungs. The condition is the result of mutations in the CFTR gene, which is responsible for producing a protein that regulates the movement of chloride and bicarbonate across cell membranes....

Published: 9/12/2024 | Inventor(s): Yong Cheng, Xuejuan Tan

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Category(s): Technology Classifications > Biotech & Pharmaceutical

Homology-based derivation of structure-function rule for protein families

BACKGROUND A long-standing challenge within protein science and engineering is that different members of a protein family have functionally distinct properties. It is observable that two members of a protein family each have a property which is helpful for a specific application. For example, if one homolog can exhibit high thermal stability while...

Published: 8/7/2023 | Inventor(s): Wouter Hoff, Rosalie Dohmen

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Category(s): Technology Classifications > Biotech & Pharmaceutical

A Novel Treatment for Cystic Fibrosis Patients with Non-Tuberculous Mycobacterial Infection

BACKGROUND Non-tuberculous Mycobacteria (NTM) are a group of opportunistic bacterial pathogens, which can cause severe pulmonary infections in people with an immunocompromised condition, such as cystic fibrosis (CF). 2,990 people died primarily from NTM in the United States between 1999-2010; these data also show a significant increase in deaths across...

Published: 5/31/2023 | Inventor(s): Yong Cheng, Jeffrey Schorey, Xuejuan Tan

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Multiplex-Based Assay to Characterize ADAMTS13 Properties and Function

BACKGROUND The metalloprotease ADAMTS13 regulates the platelet adhesion by von Willebrand factor (VWF) by severing large, prothrombotic VWF-Platelet aggregates. Genetic or autoimmune deficiency of ADAMTS13 impairs this regulatory mechanism causing thrombotic thrombocytopenic purpura (TTP), a rare fatal blood clotting disorder characterized by microangiopathic...

Published: 9/6/2024 | Inventor(s): Joshua Muia, Frida Miranda

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Cellular Senescence as a Biomarker for Cystic Fibrosis Lung Disease

BACKGROUND Cystic fibrosis (CF) is a genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and affects ~30,000 people in the USA alone. Microbial lung infections are currently one of the main causes of mortality and morbidity in CF patients. 2,990 people died primarily from non-tuberculosis mycobacterial...

Published: 5/31/2023 | Inventor(s): Yong Cheng, Xuejuan Tan

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

The Development of a Novel Synthesis and Structure of Trifluoro-THC

BACKGROUND The endocannabinoid system is part of both the central and peripheral nervous systems, playing roles in physiological, cognitive, and immune functions. Research over the past three decades has helped parse receptor pathways and shown that cannabinoid compounds like tetrahydrocannabinol (THC) have potential as pharmaceutical structures. However,...

Published: 11/6/2023 | Inventor(s): Sascha Grotjahn, Burkhard Koenig, Jon Day, Sameera Senaweera, Jimmie Weaver

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Category(s): Technology Classifications > Biotech & Pharmaceutical

Artificial Intelligence Enabled Software for Mechanical Characterizations of Thin, Soft, Heterogeneous Bio-Tissues

BACKGROUND Heterogeneous membranes or films are thin and soft structures with spatial variations in material property and thickness. Important heterogeneous membranes include bio tissues such as heart valves, eardrum membranes, skin, as well as artificial synthesized bio-compatible tissues, non-woven materials. Mechanical behavior of heterogeneous...

Published: 8/18/2023 | Inventor(s): Lin Guo, Shuodao Wang, Yuan Zhang

Keywords(s): Biotech & Pharmaceutical, Medical Device & Diagnostic, Software: AI, Neural Network & Learning

Category(s): Technology Classifications > Software, Technology Classifications > Biotech & Pharmaceutical, Technology Classifications > Medical Device & Diagnostic

Adaptive Pore Size Smart Material

BACKGROUND Prosthetic limbs are typically mounted to the remnant limb via a sleeve, which are made from a variety of materials, but mostly from silicone elastomers. Unfortunately, these sleeves heat up the limb remnant and can lose grip as the temperature increases and sweating occurs. This problem is addressed via two approaches: medical treatments...

Published: 5/24/2023 | Inventor(s): Katelynn Harmon, Aurelie Azoug

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Category(s): Technology Classifications > Chemistry, Technology Classifications > Biotech & Pharmaceutical, Technology Classifications > Material Science & Engr, Technology Classifications > Engineering, Technology Classifications > Advanced Manufacturing, Technology Classifications > Medical Device & Diagnostic

Bovine Viral Diarrhea Virus (BVDV) Subtype 2b Grown in Bovine Monolayer Cell Cultures as Cytopathic (CP) Strains for Vaccine Production, Diagnostic Testing, and Serology

BACKGROUND BVDV is the most costly disease in the cattle industry, estimated at around 2 billion per year. Often without visible symptoms, this disease inhibits conception, causes spontaneous abortion and birth defects, and hinders the immune system. BVDVb1 is the predominant source of persistently infected (PI) cattle, and there is a growing prevalence...

Published: 7/17/2023 | Inventor(s): Julia Ridpath, Jeremiah Saliki, Lurinda Burge, Robert Fulton

Keywords(s): Animal Health

Category(s): Technology Classifications > Medical Device & Diagnostic, Technology Classifications > Biotech & Pharmaceutical

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