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Apparatus and Methods to Assess Sub-Surface Tissue Properties

BACKGROUND Knowing the optical properties of a material below the layer able to be visualized via machine without contact, invasion, or destruction of the material is highly useful for quality control or monitoring purposes. Unfortunately, current technology cannot provide the ability to non-destructively identify and assess properties beneath the...

Published: 12/18/2023 | Inventor(s): Daqing Piao

Keywords(s): Agriculture & Food Science, Animal Health, Engineering: Ag & Bio, Engineering: Electrical & Computer, Hardware, Medical Device & Diagnostic, Sensors

Category(s): Technology Classifications > Engineering > Electrical & Computer Engr, Technology Classifications > Research Tools, Technology Classifications > Medical Device & Diagnostic, Technology Classifications > Agriculture & Food Science, Technology Classifications > Animal Health, Technology Classifications > Engineering > Biosystems & Ag Engr

Selective Liquid Transport Surface for Sample Separation and Analysis

BACKGROUND Miniature, cost-effective devices for sample separation have long been desired for medical diagnostics as well as analysis in areas such as process control and environmental monitoring. Traditional sample separation methods such as centrifugation, solvent extraction, and liquid-liquid phase separation require complex instrumentation...

Published: 5/17/2023 | Inventor(s): Yu Mao, Mengfan (Michael) Zhu

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Category(s): Technology Classifications > Agriculture & Food Science, Technology Classifications > Research Tools

Protein Disulfide Isomerase as a Novel Treatment for Diabetic Patients

BACKGROUND Diabetes is an epidemic disease, affecting over 350 million people worldwide, with as many as one in three American adults being afflicted with it by 2050 if current trends continue. It is defined by a sustained state of hyperglycemia, resulting from decreased glucose uptake into insulin-sensitive tissues (i.e., striated muscle and...

Published: 10/25/2024 | Inventor(s): Matthew Rochowski, Allison Campolo, Veronique Lacombe

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Category(s): Technology Classifications > Biotech & Pharmaceutical, Technology Classifications > Research Tools

Graphical User Interphase (GUI) Bioinformatic tool for the rapid detection of plant pathogens in next generation sequencing data - MiFi (R)

BACKGROUND Pathogen detection has always been a challenge in diagnostics. Current techniques like polymerase chain reaction (PCR) or bacterial/viral culture are reliable but carry some pitfalls. Primarily, PCR techniques are unable to detect more than five targets, and culturing methods are incredibly time consuming. Recently, metagenomic sequencing...

Published: 5/24/2023 | Inventor(s): Ulrich Melcher, Peter Hoyt, Kitty Cardwell, Andres Espindola Camacho

Keywords(s): Research Tools & Methods

Category(s): Technology Classifications > Agriculture & Food Science, Technology Classifications > Biotech & Pharmaceutical, Technology Classifications > Medical Device & Diagnostic, Technology Classifications > Research Tools, Technology Classifications > Software

Microbe Finder MiFi (R) Accurate Detection of Pathogens in Plants & Animal Samples Using Next Gen Sequencing

Published: 5/31/2023 | Inventor(s): Andres Espindola Camacho, Kitty Cardwell

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Category(s): Technology Classifications > Agriculture & Food Science, Technology Classifications > Medical Device & Diagnostic, Technology Classifications > Software, Technology Classifications > Research Tools

Incorporation of the Horseradish Peroxidase Gene in a Viral Genome Provides a Rapid and Cost-effective in vitro Method to Determine the Antiviral Potential of Antibodies or Drugs

BACKGROUND In-vitro virus neutralization assays are an important step in determining potential in-vivo efficacy of vaccines or (synthetic) anti-viral antibodies. Most recent micro-neutralization assays are based on luciferase or fluorescence read-outs. Viruses of interest are modified by inserting genes encoding luciferase or fluorescent proteins....

Published: 5/31/2023 | Inventor(s): Pramila Lamichhane, Antonius (Tom) Oomens

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Category(s): Technology Classifications > Research Tools, Technology Classifications > Biotech & Pharmaceutical

Combining site-directed mutations and reconstitution with a locked chromophore analog converts photoactive yellow protein into a highly fluorescent protein tag

BACKGROUND Fluorescent protein tags, such as green fluorescent protein (GFP), exhibit fluorescence when viewed under ultraviolet light. Since these tags make it possible to 'see' metabolic interactions, attaching them to proteins, antibodies, and amino acids allows researchers to study interactions between biomolecules and thus improve our...

Published: 10/19/2022 | Inventor(s): Masato Kumauchi, Branden Carr, Wouter Hoff

Keywords(s): Research Tools & Methods

Category(s): Technology Classifications > Research Tools

Estimation of the Age of Body Fluid Stains Using RNA Degradation and a Novel qPCR Approach

BACKGROUND Forensic laboratories frequently quantitate the amount of human genomic DNA recovered from evidentiary biological fluid samples. Additionally, forensic experts are often called into court to testify as to when a particular biological fluid sample was deposited at a crime scene. The time of deposit of a biological fluid sample remains a critical...

Published: 5/31/2023 | Inventor(s): Jun Fu, Robert Allen

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Medical Device & Diagnostic, Technology Classifications > Research Tools